Abstract: The surface complex support ZrO2-SiO2 (ZrSiO) was prepared by surface reaction modification, and Ni-Cu/ZrSiO bimetallic catalyst was prepared by isovolumic impregnation. Adsorption and reaction of CH4 with H2O and O2 on the catalyst were characterized by IR, TPD, TPSR and microreactor techniques. The results showed that there exist three kinds of active sites on the catalyst: metal site M, Lewis acid site Znn+ and Lewis basic site Zr-O－. With the cooperation of metal site M, Lewis acid site Znn+ and Lewis basic site Zr-O－, CH4 was activated and dissociated into CO and H2, H2O was dissociated into H2 and O on the catalyst. Under condition of reaction temperature 450 ℃, n(CH4)∶ n(O2)∶ n(H2O)=1∶0.5∶2.5 and methane space velocity (SVCH4)＝1200h－1, the main reaction products on Ni-Cu/ZrSiO catalyst are H2 and CO2, with a selectivity over 95%.