Honeycomb cordierite based CuO/Al2O3 catalyst was studied for simultaneous SO2 and NO removal from flue gas. It is found that the addition of sodium in the catalyst can improve SO2 removal activity. However, the sodium addition will slightly decrease NO removal activity due to the increased NH3 oxidation. With increasing the reaction temperature from 350℃ to 450℃, the SO2 removal activity increases, while the NO removal activity decreases due to the increased NH3 oxidation. Space velocity shows a slight effect on NO removal in the range of 1450h-1~3600h-1, but a strong effect on SO2 removal activity. A catalyst composition, 6.0 % copper and 2.0 % sodium, was found to be optimal for simultaneous SO2 and NO removal. The suitable reaction temperature and space velocity are about 400 ℃ and 2 300 h-1 or below, respectively.